ALI, AMJAD,LO, MICHAEL MAN-CHU,METZGER, EDWARD,YAN, LIN
申请号：
MX2012009340
公开号：
MX2012009340A
申请日:
2011.02.10
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, -OH, -O-C1-6 alkyl, =O, or halogenR2 is hydrogen, C(O)OR8, C6H5C(O)OR8, (CH2)1-2OH, CR9R10OH, C(O)O(CH2)0-2 aryl, C(O)NR9R10, C(O)SO2NR9R10, C6H5OR9, W-C(O)OR8, W-OR9, Y, or P(O)(OR9)(ORlO) R3 is hydrogen or -C1-6 alkyl R4 is hydrogen, -OH or -C(O)OR9 R5 is hydrogen or deuterium R6 and R7 are independently-C1-6 alkyl, fluoro-substituted -C1-6 alkyl, deutero-substituted -C1-6 alkyl or -(CH2)1-2R11, wherein any carbon atom of the fluoro-substituted -C1-6 alkyl is mono- or di-substituted with fluoro, and any carbon atom of the deutero-substituted -C 1-6 alkyl is mono- or di-substituted with fluoro R8, in each instance in which it occurs, is independently hydrogen, -C1-6 alkyl, or -(CH2)2N+(CH3) 3 R9 and R10, in each instance in which they occur, are independently -C1-6 alkyl R11 is -OH, -O-C 1-6 alkyl, -0CD3, -OC(O)OC 1-6 alkyl, -NH2, -C6H5, -N3, or W W is an unsubslituted 5- or 6-raembered heteroaryl ring having 1, 2, or 3 nitrogen atoms, or a substituted 5- or 6-membered heteroaryl ring having 1, 2, or 3 nitrogen atoms that is mono- or di-substituted at any carbon atom with R6 or R7 Y is a 5- or 6-membered heterocyclic ring having 1, 2, 3 or 4 heteroatoms which are N, O or S or stereoisomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof, and methods of using the compounds for treating hypertension.Un compuesto que tiene la estructura (Ver Formula) o una sal farmacéuticamente aceptable del mismo, en donde R1 es hidrógeno, -OH, -O-alquilo de C1-6 , =O, o halógeno R2 es hidrógeno, -C(O)0R8, -C6H5C(O)OR8, -(CH2)1-20H, -CR9R10OH, -C(O)O(CH2)0-2 arilo, -C(O)NR9R10, -C(O)S02NR9R10, -C6H50R9, -W-C(O)0R8, -W-OR9,-Y, o -P(O)(0R9)(0R10) R3 es hidrógeno o -alquilo de C1-6 R4 es hidrógeno, -OH, o -C(O)0R9 R5 es hidrógeno o deuterio R6 y R7 son independientemente -alquilo de C1-6, -alquilo de C1-6 fluoro susti
