ALI AMJAD,LO MICHAEL MAN-CHU,METZGER EDWARD,YAN LIN
申请号：
IN6671/CHENP/2012
公开号：
IN2012CN06671A
申请日:
2012.07.27
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
1 162 865821 291020 2910291065989931 6495671 61 61 621 2111 61 681 622+339101 611 1 61 6265367A compound having the structure or a pharmaceutically acceptable salt thereof wherein R is hydrogen OH O C alkyl =O or halogenRis hydrogen C(O)OR CHC(O)OR (CH)OH CRROH C(O)O(CH) aryl C(O)NRR C(O)SONRR CHOR W C(O)OR W OR Y or P(O)(OR)(ORlO) R is hydrogen or C alkyl R is hydrogen OH or C(O)OR R is hydrogen or deuterium R and R are independently C alkyl fluoro substituted C alkyl deutero substituted C alkyl or (CH)R wherein any carbon atom of the fluoro substituted C alkyl is mono or di substituted with fluoro and any carbon atom of the deutero substituted C alkyl is mono or di substituted with fluoro R in each instance in which it occurs is independently hydrogen C alkyl or (CH)N(CH) R and R in each instance in which they occur are independently C alkyl Ris OH O C alkyl 0CD3 OC(O)OC alkyl NH CH N or W W is an unsubslituted 5 or 6 raembered heteroaryl ring having 1 2 or 3 nitrogen atoms or a substituted 5 or 6 membered heteroaryl ring having 1 2 or 3 nitrogen atoms that is mono or di substituted at any carbon atom with R or R Y is a 5 or 6 membered heterocyclic ring having 1 2 3 or 4 heteroatoms which are N O or S or stereoisomers thereof or pharmaceutically acceptable salts thereof or pharmaceutically acceptable salts of stereoisomers thereof and methods of using the compounds for treating hypertension.
