CURRY, JAYNE ELIZABETH,LYONS, JOHN FRANCIS,SQUIRES, MATTHEW SIMON,THOMPSON, NEIL THOMAS,THOMPSON, KYLA MERRIOM,WYATT, PAUL GRAHAM
申请号：
CA2594477
公开号：
CA2594477C
申请日:
2006.01.20
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides a combination of an ancillary agent and a compoundhaving the formula (0): or salts or tautomers or N-oxides or solvates thereofwherein the ancillary agent is selected from: a monoclonal antibody, analkylating agent, an anticancer agent, a further CDK inhibitor and a hormone,hormone agonist, hormone antagonist or hormone modulating agent X is a groupR1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring A is a bond,SO2, C=O, NR9(C=O) or 0(C=O) wherein R9 is hydrogen or C1-4hydrocarbyloptionally substituted by hydroxy or C1-4 alkoxy Y is a bond or an alkylenechain of 1 , 2 or 3 carbon atoms in length R1 is hydrogen a carbocyclic orheterocyclic group having from 3 to 12 ring members or a C1-8 hydrocarbylgroup optionally substituted by one or more substituents selected from halogen(e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl groupmay optionally be replaced by an atom or group selected from O, S, NH, SO,SO2 R2 is hydrogen halogen C1-4alkoxy (e.g. methoxy) or a C1-4 hydrocarbylgroup optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4alkoxy (e.g. methoxy) R3 is selected from hydrogen and carbocyclic andheterocyclic groups having from 3 to 12 ring members and R4 is hydrogen or aC1-4hydrocarbyl group optionally substituted by halogen (e.g. fluorine),hydroxyl or C1-4 alkoxy (e.g. methoxy).
