Thompson, Kyla Merriom,Curry, Jayne Elizabeth,Squires, Matthew Simon,Wyatt, Paul Graham,Thompson, Neil Thomas,Lyons, John Francis
申请号：
AU2006207325
公开号：
AU2006207325B2
申请日:
2006.01.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides a combination of an ancillary agent and a compound havingthe formula (0): or salts or tautomers or N-oxides or solvates thereof； whereinthe ancillary agent is selected from: a monoclonal antibody, an alkylating agent,an anticancer agent, a further CDK inhibitor and a hormone, hormone agonist,hormone antagonist or hormone modulating agent； X is a group R-A-NR-or a 5- or 6-membered carbocyclic or heterocyclic ring； A is a bond, SO,C=O, NR(C=O) or 0(C=O) wherein R is hydrogen or Chydrocarbyl optionally substituted by hydroxy or Calkoxy；Y is a bond or an alkylene chain of 1 , 2 or 3 carbon atoms in length； R ishydrogen； a carbocyclic or heterocyclic group having from 3 to 12 ring members；or a C hydrocarbyl group optionally substituted by one or more substituentsselected from halogen (e.g. fluorine), hydroxy, Chydrocarbyloxy,amino, mono- or di-Chydrocarbylamino, and carbocyclic or heterocyclicgroups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms ofthe hydrocarbyl group may optionally be replaced by an atom or group selectedfrom O, S, NH, SO, SO； R is hydrogen； halogen； Calkoxy (e.g. methoxy)； or a Chydrocarbyl group optionallysubstituted by halogen (e.g. fluorine), hydroxyl or Calkoxy (e.g.methoxy)； Ris selected from hydrogen and carbocyclic and heterocyclicgroups having from 3 to 12 ring members； and R is hydrogen or a Chydrocarbyl group optionally substituted by halogen (e.g. fluorine),hydroxyl or Calkoxy (e.g. methoxy).
