Thompson, Neil Thomas,Wyatt, Paul Graham,Curry, Jayne Elizabeth,Lyons, John Francis,Thompson, Kyla Merriom,Squires, Matthew Simon
申请号：
AU2006207321
公开号：
AU2006207321B2
申请日:
2006.01.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides a combination of a cytotoxic compound or signalling inhibitorand a compound having the formula (0): or salts or tautomers or N-oxides or solvatesthereof； wherein X is a group R-A-NR- or a 5- or 6-memberedcarbocyclic or heterocyclic ring； A is a bond, SO, C=O, NR(C=O)or 0(C=O) wherein R is hydrogen or Chydrocarbyl optionallysubstituted by hydroxy or Calkoxy； Y is a bond or an alkylene chainof 1, 2 or 3 carbon atoms in length； R is hydrogen； a carbocyclic or heterocyclicgroup having from 3 to 12 ring members； or a Chydrocarbyl group optionallysubstituted by one or more substituents selected from halogen (e.g. fluorine),hydroxy, Chydrocarbyloxy, amino, mono- or di-Chydrocarbylamino,and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced byan atom or group selected from O, S, NH, SO, SO； R is hydrogen；halogen； Calkoxy (e.g. methoxy)； or a Chydrocarbylgroup optionally substituted by halogen (e.g. fluorine), hydroxyl or Calkoxy (e.g. methoxy)； R is selected from hydrogen and carbocyclicand heterocyclic groups having from 3 to 12 ring members； and R is hydrogenor a Chydrocarbyl group optionally substituted by halogen (e.g.fluorine), hydroxyl or Calkoxy (e.g. methoxy).
