1. The compound of formula (I):, or a pharmaceutically acceptable salt, solvate, hydrate, prodrug or derivative thereof, wherein Z is selected from CF, C 1 -C 4 alkoxy, CFO, halogen, cyano and C 1 -C 6 alkyl optionally substituted with one or more halogens； Y is selected from halogen, C 1 -Calkoxy, hydroxyl, CFO and cyano； W is selected from oxygen, sulfur and two hydrogen atoms； R and R are independently selected from C-Calkyl optionally substituted with one or more fluorine atoms or hydroxyl groups, or R and R are carbon atoms to which they are attached form a 3-6 membered cycloalkyl stake where one or more carbon atoms may optionally be substituted with one or more fluorine atoms or hydroxyl groups, and where one of the carbon atoms is optionally substituted with oxygen or nitrogen； It is an aryl group or a heteroaryl group optionally substituted with one or more C 1-6 alkyl, cyano , hydroxyl, methoxy, ethoxy, halogen or a 5-6 membered heteroaryl group； A is (CF) (CH) Y (CH) Q, where a, m and n are integers independently selected from 0-4, and where, at least one of a or m or n is not zero, or A S THE (CH) Y (CH) Q, where m and n are integers independently selected from 0-4, and wherein at least one of m or n is not zero； Q is selected from C (O) NHR ", C (RR) C (O) NR" R ", SOR", SONR "R", cyano, hydroxyl, C-Calkoxy, C (S) NR "R", C ( O) OR ", OC (O) NR" R ", C (O) NR" R ", an optionally substituted 5-6 membered heteroaryl and an optionally substituted 4-6 membered heterocycle； and Y is selected from a direct bond, -O- , -S- and -NR "-； R "and R" are independently selected from hydrogen, C 1-6 alkyl, C 1-6 cycloalkyl and C 1-6 alkenyl, or NR "R" together form a 3-7 membered heterocyclic ring where one or more carbon atoms may optionally be substituted with one or more hydroxyl, amino, cyano or fluorine； R and R are independently selected from hydrogen or methyl； or C (RR) together1. Соединение формулы (I):,или его фармацевтически приемлемая соль, сольват, гидрат
