ХАРРИС Кит Дж. (US),АГИАР Жуаси К. (US),ШУМ Патрик Ваи-Квок (US),ЧЖАО Чжичэн (US),ПОЛИ Грегори Б. (US),СТОКЛОЗА Грегори (US),ЧОИ-СЛЕДЕСКИ Йонг-Ми (US),РАЙЛИНГ Штефан (US),СТЕФАНИ Дэвид (US),ГАРДНЕР Ча
申请号：
RU2012143897/04
公开号：
RU2012143897A
申请日:
2011.03.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula (I) where m and n are independently selected from integers 0, 1, 2 or 3； X and Y are independently selected from CRR, NR or O, where X and Y cannot simultaneously be O ； or X and Y, taken together with the bond between them, form a phenyl group optionally substituted with one to four R groups； each Z independently represents CRR； R, R and R are independently selected from the group containing H, halogen , aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, as well as carboxy； where optionally substituted th alkyl may be substituted by one to three identical or different groups selected from halogen, carboxy, cyano, hydroxy, amino or aryl； where optionally substituted alkoxy may be substituted by one to three identical or different groups selected from halogen, carboxy, cyano, amino or aryl； where each aryl moiety independently of each other may optionally be substituted with hydroxy, amino, alkyl, alkoxy, carboxy or alkoxycarbonyl； provided that the halogen cannot be bound to N； and provided that the compound is not (1- {2-methoxy-6- [2- (4-trifluoromethoxyphenyl) ethylamino] pyrimidin-4-yl} piperidin-3-yl) acetic acid； or its enantiomer or its prodrug or pharmaceutically acceptable salt. 2. The compound according to claim 1, selected from the group consisting of: 4- {2-methoxy-6- [2- (4-trifluoromethoxyphenyl) ethylamino] pyrimidin-4-yl} morpholine-2-carboxylic acid, (4- {2- methoxy-6- [2- (4-trifluoromethoxyphenyl) ethylamino] pyrimidin-4-yl} piperazin-1-yl) acetic acid, 1- {2-methoxy-6- [2- (4-trifluoromethoxyphenyl) ethylamino] pyrimidine- 4-yl} piperidin-2-carboxylic acid, (1- {2-methoxy-6- [2- (4-trifluoromethoxyphenyl) ethyl1. Соединение формулы (I)где m и n независимо друг от друга выбраны из целых чисел 0, 1, 2 или 3；X и Y независимо друг от друга выбраны из CRR, NRили O, где X и Y одновременно не могут быть O；или X и Y, взятые вместе со связью между ними, образуют фенильную группу, необязательно замещенную о
