CLASS OF CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN PREPARATION OF PRODRUGS

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专利权人:

Li; Qingeng

发明人:

WANG, Tao,CHEN, Gang,WANG, Yuanzhong,MAO, Wei,WU, Tong,ZENG, Lingguo

申请号：

EP15748471

公开号：

EP3109230A4

申请日:

2015.02.16

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein R 1 is H or alkyl X is H or F Y is F or fluoroalkyl n is 0, 1, 2, 3, 4, 5, or 6 W is W 1 or W 2 W 1 is NR 2 R 3 NR 2 R 3 ·A, R 2 and R 3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino m is 0, 1, 2, or 3 A is an acid W 2 is COOR 4 , OPO(OR 4 ) 2 , or PO(OR 4 ) 2 R 4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid.

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