ШНЕЙДЕР Л. Уэйн (US),ХАН Уэсли Вехсин (US),ЧОВХАН Масуд А. (US)
申请号：
RU2012117141/15
公开号：
RU2012117141A
申请日:
2010.10.01
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A pharmaceutical composition in the form of an aqueous solution containing a therapeutically effective amount of olopatadine or a pharmaceutically acceptable salt thereof in the soluble form in the aqueous phase, a PDE4 inhibitor, which is a compound of formula I or a pharmaceutically acceptable salt thereof, wherein R and R groups are independently selected from the group consisting of - ( CH) GGG, acyl, acylalkyl, carboxyalkyl, cyanoalkyl, alkoxy, alkoxyalkyl, amidoalkyl, amino, alkyl, alkylalkoxy, aminoalkyl, alkenyl, alkynyl, carboxyl, carboxyalkyl, ether a, heteroalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aralkyl, aryl, guanidine, heteroaryl, heteroalkyl and hydroxyalkyl, any of which may be optionally substituted； s = 1-8； an amino group selected from , amido, carbonyl, hydroxy, ether, amino acids and zero； the G group is selected from the group consisting of alkyl, alkoxy, amino, aryl, halogen, haloalkyl, heterocycloalkyl, heteroaryl, carboxyalkylamino, guanidine, amino acids and zero, any of which may optionally be substituted； the group G is selected from the group consisting of alkyl, alkoxy, amino, hydroxy, ether, carboxyl, hydroxamic acid, amino acids, phosphonate, phosphamide and zero, any of which may be optionally substituted； the group R is selected from the group, consisting of - (CRR) W (CRR) - and - (CRR) -； the group W is selected from the group consisting of O, N (R), C (O) N (R) and SO； m, n and q independently are 0, 1 or 2； p = 1 or 2； the R group is selected from the group consisting of carboxyl, alkyl carboxy, amido, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkyl, gete1. Фармацевтическая композиция в виде водного раствора, содержащаятерапевтически эффективное количество олопатадина или его фармацевтически приемлемой соли в виде растворимой формы в водной фазе,ингибитор PDE4, представляющий собой соединение формулы Iили его фармацевтически приемлемую соль, гдегруппы Rи Rнезависимо выбран
