A middleman prepares to use it as a drug, and drugs including it. Claim 1: a formula compound (1) or a formula salt, wherein: R 1 is c832131 asphalt；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₃₋₆ cycloalkyl,C₅₋₆ cycloalkenyl or C₃₋₆ cycloalkyl-C alquilo alkyl；where this C₁₋₆ alkyl,C₂₋₆ alkenyl,C₂₋₆ alkynyl or C₃₋₆ cycloalkyl-C₁₋₄ alkyl may be substituted once or more than once by halogen, hydroxyl, or C₁₋₄ alkoxy；and wherein the C₃₋₆ cycloalkyl or C₅₋₆ cycloalkenyl may be substituted once or more than once by halogen, hydroxyl, C₁₋₄ alkyl,halo-C₁₋₄ alkyl,hydroxy-C₁₋₄ alkyl or C₁₋₄ alkoxy；m is 1 or 2； n is 0, 1, 2, 3 or 4； Each R² is independently halogen, hydroxyl, amino, cyano, nitro, C₁₋₆ alkyl,halo-C₁₋₆ alkyl,hydroxy-C₁₋₆ alkyl,C₁₋₄ alkoxy-C₁₋₆ alkyl,amino C₁₋₆ alkyl,C₁₋₄-amino-C₁₋₆ alkyl,di- (alquilo C) -amino-alquilo CC₁₋₆ alkoxy,C₁₋₆ haloalkoxy,alquilo C -amino di- (alquilo C) -amino alquenilo CC₂₋₆ halo-alkenyl,C₂₋₆ alkynyl or C₂₋₆ haloalkynyl；or C₃₋₆ cycloalkyl,wherein a carbon atom can be replaced by an oxygen atom, where the C₃₋₆ cycloalkyl can be attached directly to methylene or by means of a C₁₋₂ alkylene,and wherein the C₃₋₆ cycloalkyl may be substituted once or more than once by halogen； or two R² in the same carbon atom form, together with that carbon atom, a C₃₋₆ cycloalkyl；X1 is oxygen o-n (r830808) -；R83088 is hydrogen, c832131 matrix 832626；C₃₋₆ cycloalkyl,or C₃₋₆-C₁₋₂ cycloalkyl；P is equal to 1, q is equal to 1, P is equal to 0, q is equal to 1, or P is equal to 0, q is equal to 0, R is equal to 0, 1, 2, 3 or 4, each cubic meter is independent halogen, hydroxyl, ammonia, cyanogen, nitrogen, hydrocarbon c83318326；halo-C₁₋₆ alkyl,hydroxy-C₁₋₆ alkyl,C₁₋₄ alkoxy-C₁₋₆ alkyl,amino C₁₋₆ alkyl,C₁₋₄-amino-C₁₋₆ alkyl,di- (alquilo C) -amino-alquilo CC₁₋₆ alkoxy,C₁₋₆ haloalkoxy,alquilo C -amino di- (alquilo C) -amino alquenilo CC₂₋₆ halo-alkenyl,C₂₋₆ alkynyl or C₂₋₆ haloalkynyl；or C₃₋₆ cycloalkyl,wherein a carbon atom can be replaced by an oxygen atom, where the C
