This invention relates to compounds of the formula 0, or a salt, tautomer, N- oxide or a solvent Freight andA monoclonal antibody, alkylating agents, anticancer agents, CDK inhibitors, and added hormones, hormone agonists, hormone antagonists or hormone supplements selected from regulatorscombination that contains a provides& lt Formula 0 & gtformula,X is R 1 -A-NR 4 - group, or a 5-or 6-membered carbocyclic or heterocyclic ringA is a bond, SO 2 , C = O, NR g (C = O) or O (C = O) and wherein R g is hydrogen, or hydroxy, or C 1-4 alkoxy optionally substituted with C 1-4 is hydrocarbylY is a bond, or one, two or three carbon atoms of the alkylene chain length andR 1 is hydrogen Click carbocyclic having 3 to 12 ring members or a heterocyclic group Or halogen (e.g., fluorine), hydroxy, C 1-4 hydrocarbyl oxy, amino, mono- or di -C 1-4 hydrocarbyl amino, and from 3 to 12 ring members with one or more substituents selected from carbocyclic or heterocyclic group having an optionally substituted C 1-8 hydrocarbyl group, the hydrocarbyl group carbon atoms, containing one or two O, S, NH, SO, SO may be replaced 2 atom or a group selected from optionallyR 2 is hydrogen Halogen C 1-4 alkoxy (e.g., methoxy) Or halogen (e.g., fluorine), hydroxy or C 1-4 alkoxy (e.g., methoxy) C optionally substituted with 1-4 hydrocarbyl and prayR 3 is selected from carbocyclic and heterocyclic group having a hydrogen, and 3 to 12 ring membersR 4 is hydrogen, or halogen (e.g., fluorine), hydroxy or C 1-4 alkoxy (e.g., methoxy) optionally substituted by C 1-4 is hydrocarbyl.본 발명은 하기 화학식 0의 화합물, 또는 그의 염, 호변 이성체, N-옥시드 또는 용매화물 및모노클로날 항체, 알킬화제, 항암제, 추가 CDK 억제제 및 호르몬, 호르몬 아고니스트, 호르몬 안타고니스트 또는 호르몬 조절제로부터 선택되는 보조제를 포함하는 조합물을 제공한다<화학식 0>식 중,X는 R1-A-NR4-기, 또는 5- 또는 6-원의 카르보시클릭 또는 헤테로시클릭 고리이고A는 결합, SO2, C=O, NRg(C=O) 또는 O(C=O)이고, 상기 Rg는 수소, 또는 히드록시 또는 C1-4 알콕시로 임의로 치환된 C1-4 히드로카르빌이고Y는 결합, 또는 1, 2 또는 3 개의 탄소 원자 길이의 알킬렌 쇄이고R1은 수소 3 내지 12 개의 고리원을 갖는 카르보시클릭 또는 헤테로시클릭기
