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Heterocyclic derivatives as opioid receptor modulators
专利权人:
Janssen Pharmaceutica NV
发明人:
Breslin, Henry J.,He, Wei,Kavash, Robert W.
申请号:
ES10180687
公开号:
ES2608840T3
申请日:
2003.04.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula (II) ** Formula ** in which: M1 is selected from the group consisting of hydroxy, C1-6 alkyl, C1-6 alkoxy, amino, C1-6 alkylamino, dialkylamino (C1-6) and -NR37R38, wherein R37 and R38 are independently selected from the group consisting of C1-6 alkyl optionally substituted with hydroxy, C1-4 alkoxy, C1-4 alkylamino, mercapto, C1-4 alkylmercapto; when R37 and R38 are present in the same substituent group, R37 and R38 can optionally be taken together to form a 5 to 8 member ring; M2 is selected from the group consisting of hydroxy and C1-6 alkoxy; Y is CH or a nitrogen atom; R30 and R31 are independently selected from the group consisting of C1-6 alkyl, C1-6 alkoxy substituted with hydroxy and amino, and halogen; R32 and R33 are independently selected from the group consisting of hydrogen and C1-6 alkyl; R34 is selected from the group consisting of hydrogen and C1-6 alkyl; and R35 and R36 are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-8 alkyl, C 1-6 alkyl, C 1-6 alkyl, C 1-6 alkyl (C) , aryl -C (O), heteroaryl -C (O) and phenyl; wherein: the alkyl is a saturated straight or branched chain consisting of only 1-6 carbon atoms substituted with hydrogen or a mixture of carbon atoms substituted with hydrogen and substituted with fluorine where there may be 1-3 fluorine atoms in each carbon atom as long as the total number of fluorine atoms does not exceed 3 and the total number of carbon atoms does not exceed 6; the alkoxy is -O-alkyl, wherein the alkyl is as defined above; aryl is a phenyl or naphthyl group; the heteroaryl is an aromatic monocyclic ring system containing from five to six members of which at least one member is an N, O or S atom and optionally containing N, S or O atoms; or the heteroaryl is an aromatic bicyclic ring having nine to ten members of which at least one member is an N, O or S atom and optionally containing additional N, S or O atoms; the aryl or heteroaryl may be optionally substituted
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