IWEMA BAKKER, WOUTER I.,KEIZER, HISKIAS G.,NEUT, VAN DER,KRUSE, CORNELIS G.,LOEVEZIJN, VAN,ZORGDRAGER, JAN
申请号：
ES07820387
公开号：
ES2377996T3
申请日:
2007.09.20
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compound of formula (1): or a tautomer, stereoisomer, N-oxide, or a pharmacologically acceptable salt, hydrate or solvate of any of the foregoing in which: R1 represents hydrogen, an unsubstituted (C1-4) alkyl group , a (C1-4) alkyl group substituted with one or more halogen atoms, - R2 and R3 independently represent hydrogen, an unsubstituted (C1-4) alkyl group, a (C1-4) alkyl group substituted with one or more Halogen atoms, oR1 and R2, together with the carbon atoms labeled `a 'and` b' form a C5-8 cycloalkyl ring, oR2 and R3, together with the carbon atom labeled `b 'form a C3- cycloalkyl ring 8, oR2 and R3, together with the carbon atom labeled `b 'form a C5-8 heterocycloalkyl ring unsubstituted or substituted with one several Y substituents, chosen from (C1-3) alkyl, trifluoromethyl, fluoro, chloro, bromo, hydroxyl, (C1-3) alkyloxy, triofluoromethoxy, and amino, o- R4 and R5 independently represent and hydrogen, an unsubstituted (C1-4) alkyl group, a (C1-4) alkyl group substituted with one or more halogen atoms, a fused monocyclic or bicyclic aromatic or heteroaromatic group whose groups are unsubstituted or substituted with one or several substituents Y as defined above or, R3 and R4, together with the carbon atoms labeled `b 'and` c' form a cycloalkyl-C3-8 ring, oR3 and R4, together with the carbon atoms labeled ` b 'and `c' form a C5-8 heterocycloalkyl ring whose groups are unsubstituted or substituted with one or more substituents Y as defined above o-R6 and R7 independently represent a hydrogen atom, or a (C1-alkyl) group -4), or a (C1-4) alkyl group substituted with one or more halogen atoms； or a (C1-3) alkoxy group, or a dialkyl (C1-3) -amino-C1-3 alkyl group, or a fused monocyclic or bicyclic aromatic or heteroaromatic group, or a C5-8 cycloalkyl group or a C5-8 heterocycloalkyl group whose cyclic groups are unsubstituted or substituted with one or more substituents Y as defined above, with the proviso that N- (4,6-dimethyl-2-pyrimidinyl) -4.5 is exclu
