YOUNG, JOSEPH MICHAEL,PFISTER, KEITH BRICE,LU, PEICHAO,KARUR, SUBRAMANIAN,HAN, WOOSEOK,FU, JIPING
申请号：
ARP180101043
公开号：
AR111419A1
申请日:
2018.04.24
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a formula compound (1),characterized in that: R¹ is H or halo； R² is independently selected at each occurrence from halo, CN, haloalkyl C₁₋₃,haloalkoxy C₁₋₃,-Orc,-N (R) RAnd substitute c83218c83331-83323 asphalt, which can be selected from R3 cubic meters by up to three groups,-N (R) RCn, oh, conr832222,-COOR, and -OR³；R³ is a C₁₋₄ alkyl which is optionally substituted with one to three groups selected from halo, C halo haloalkyl,-Oh, alcoxi c8321c83318323；haloalkoxy C₁₋₃,oxo CN -NH-NH (alquilo C)-N (alquilo C)-COOR, -CONR₂,cycloalkyl C₃₋₅,and a 4-6 membered cyclic ether, in which the C₃₋₅ cycloalkyl and the 4-6 membered cyclic ether are each optionally substituted with one or two groups selected from halo, -OH, C₁₋₃ alkoxy,and C₁₋₃-alkyl；or R³ is a C₃₋₅ cycloalkyl ring or 4-6 membered cyclic ether, wherein the C₃₋₅ cycloalkyl ring or 4-6 membered cyclic ether are each optionally substituted with one to three groups selected from halo, alkyl C₁₋₃,-Oh, alcoxi c8321c83318323；haloalkoxy C₁₋₃,Halogenated tar c83218323；-NH832222,-NH (alquilo C)y -N (alquilo C)N is 0, 1, or 2； W is - coor83088；-C (O) NH-SO R-C (O) NH-SO NR5-tetrazolyl, or 1,2,4-oxadiazol-3-yl-5 (4H) -one； R⁴ is H or C₁₋₆ alkyl which is optionally substituted with one to three groups selected from halo, -OR, oxo, CN, and -NR₂；R⁵ is C₁₋₆ alkyl which is optionally substituted with one to three groups selected from halo, -OR, oxo, CN, and -NR₂；Lease r8310h or c832131；R⁷ is H or C₁₋₆ alkyl,or R⁷ taken together with R⁹ and the atoms connecting them R⁷ with R⁹ form a ring as described below； R⁸ is H or C₁₋₆ alkyl；R⁹ is selected from: (i) H； (ii) C₁₋₆ alkyl optionally substituted with up to three groups selected from C₃₋₆ cycloalkyl,-R-no. 832222,halo CN COOR CONRand oxo； and (iii) a ring selected from (a) C₃₋₆ cycloalkyl,(b) Phenyl, (c) isomer of 5-6 containing one or two isomerized atoms selected from n or s as members of the ring, and (d) isomerized atoms of 5-6 containing one or two isomerized ato
