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Compounds 4 - oxoquinolina
专利权人:
JAPAN TOBACCO INC.
发明人:
MOTOHIDE SATO,HIROSHI KAWAKAMI,YOSHIHARU ITO,HISASHI SHINKAI,TAKAHISA MOTOMURA,HISATERU ARAMAKI,YUJI MATSUZAKI,WATARU WATANABE,SHUICHI WAMAKI
申请号:
ARP120102410
公开号:
AR087046A2
申请日:
2012.07.03
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
The Compound has inhibitory Action on HIV integrase and is useful as an anti HIV agent for the prophylaxis or Therapy of AIDS. In addition, by a combined use with other anti HIV Agents such as protease inhibitors, reverse transcriptase inhibitors and similar, the composite can be enhanced as an anti HIV Agent more effective.Because the compound has a high Inhibitory activity specific for integrasas, can provide a Pharmaceutical Agent.Claim 1: an anti HIV Agent, characterized in that it comprises a compound 4 - oxoquinolina represented by the formula (1) or a pharmaceutically acceptable Salt thereof as the active ingredientWhere Cy Group ring is a Ring of carbon c u2083 u208b u2081 u2080 optionally replaced by 1 to 5 substituents selected from the following group or a Heterocyclic Group optionally substituted by 1 to 5 substituents selected from the group to the next, which is Heterocyclic Group A Ring containing unsaturated or saturated, in addition to the carbon Atom (S)At least a heteroatom selected from a nitrogen Atom, an oxygen Atom and a Sulfur Atom; Group a group consisting of a phenyl Group, a cyano Group, a Nitro Group, halogen Atom, alkyl group c u2081 u208b u2084, haloalquilo c u2081 u208b u2084 Group, Group haloalquiloxilo c u2081 u208b u2084, - Or u1d43 u00b9 sr u1d43 u00b9 nr u1d43 u00b9r u1d43 u00b2, -, -, - conr u1d43 u00b9r u1d43 u00b2 so u2082nr u1d43 u00b9r u1d43 u00b2 cor u1d43 u00b3, -, -, Group - - - nr u1d43 u00b9so u2082r u1d43 u00b3 so u2082r u1d43 u00b3 nr u1d43 u00b9cor u1d43 u00b3,,,- coor u1d43 u00b9 and nr u1d43 u00b2coor u1d43 u00b3 Group - Where r u1d43 u00b9 and r u1d43 u00b2 are the same or different and each is Hydrogen Atom, alkyl group c u2081 u208b u2084 benzyl group or alkyl group and r u1d43 u00b3 is c u2081 u208b u2084; r u00b9 is a Substituent selected from Group B or an alkyl group c u2081 u208b u2081 u2080 OPC Ionalmente replaced by 1 to 3 Halogen Atom and substituents selected from the B Group Next,In Group B, where the g
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