ZHANG, PENGLIE,YANG, JU,SINGH, RAJINDER,PUNNA, SREENIVAS,MMURTRIE, DARREN J.,MALATHONG, VIENGKHAM,LANGE, CHRISTOPHER
申请号：
ARP170101772
公开号：
AR108891A1
申请日:
2017.06.28
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a compound characterized by the formula (1) or a pharmaceutically acceptable Salt thereof wherein, r¹ is selected from the group consisting of halogenC₅₋₈ c₆₋₁₀ cycloalkyl, aryl and tienilo,Where the c₆₋₁₀ and tienilo are optionally substituted aryl substituents with between 1 and 5 rˣ each rˣ independently selected among the group consisting of halogen, - CN, - rᶜ,Co₂rᵃ conrᵃrᵇ -, -, - C (o) - rᵃ, OC (OR) nrᵃrᵇ, nrᵇc rᵃ - (OR), (OR) - nrᵇc ₂rᶜ nrᵃ -, - C (o) nrᵃrᵇ nrᵃrᵇ orᵃ, -, -, - or - orᵃ x¹ -, - or - x¹ - co₂rᵃ, - x¹ conrᵃrᵇ or - -, - - - - x¹ orᵃ, x¹ nrᵃrᵇ co₂rᵃ x¹ -, -, - x¹ conrᵃrᵇ sf₅ -, -, and - S (o) ₂nrᵃrᵇ,Where each x¹ is a c₁₋₄ alquileno each rᵃ and rᵇ is selected independently between c₁₋₈ Hydrogen, alkyl, and c₁₋₈ haloalquilo,Or when United with the same nitrogen Atom can be combined with the nitrogen Atom to form a Ring of five or six members with between 0 and 2 additional heteroatoms as members ofL Ring selected from N, o or s,Where the five or six member ring is optionally substituted oxo each rᶜ is selected independently from the group consisting c₁₋₈ alkyl, c₂₋₈ alquenilo,C₂₋₈ alquinilo and c₁₋₈ haloalquilo and optionally when two substituents on adjacent Atoms are rˣ, combine to form a Heterocyclic FUSED Ring carbocíclico or five,Six or seven Member optionally replaced with between 1 and 3 substituents selected independently between Halo, Oxo, and c₁₋₈ haloalquilo c₁₋₈ alkyl each r²ᵃ,R²ᵇ and r²ᶜ independently selected among the group consisting of H, halogen, - CN, - rᵈ co₂rᵉ conrᵉrᶠ, -, -, - C (o) - rᵉ, OC (nrᵉrᶠ - nrᶠc or), (OR) rᵉ, nrᶠc ₂rᵈ - (OR) -, - C (o nrᵉ nrᵉrᶠ nrᵉrᶠ), -, - orᵉ,- or - - - - orᵉ X, or X - - - X - or nrᵉrᶠ, co₂rᵉ, conrᵉrᶠ - or - X - X, - - - - nrᵉrᶠ orᵉ, X, - X - X - co₂rᵉ, conrᵉrᶠ sf₅ -, -, - S (o) ₂nrᵉrᶠ, c₆₋₁₀ aryl and heteroaryl c₅₋₁₀,Where each X is a c₁₋₄ alquileno each rᵉ and rᶠ is selected independently between c₁₋₈ Hydrogen, alkyl, and c₁₋₈ haloalquilo,Or when United with the same nitrogen Atom can be
