Claim 1: a compound of formula (1), a stereoisomer of this or a pharmaceutically acceptable Salt of the compound or a stereoisomer,Where: r u00b9 R u00b2 are selected and each independently, phenyl heteroaryl c u2083 u208b u2085 or u2074, -, and - N (r u2075 r u2074), where each phenyl heteroaryl substituted c u2083 u208b u2085 is irrespective with between 0 and 3 r u1d43,Heteroaryl c u2083 u208b u2085 Atoms and each has 5 or 6 Rings which are 1 or 2 heteroatoms are selected irrespective of N, o, and S； each r u1d43 is selected regardless of Halo, CNR u00b3, and r u2074； each r u00b3 is selected regardless of or u2074 -, - N (r u2074) r u2075, nr u2074c r u2076 - (OR), (OR) or u2075 nr u2074c -, - C (o) or u2074, - C (o) n (r u2074) r u2075, - C (o) n (or u2075, r u2074) - C (o) n (r u2074) s (o) n ( u2082r u2076, r u2074) - S (o) u2082r u2076, sr u2074 -, - S - S r u2076 (OR), (OR) u2082r u2076,And - S (o) u2082n (r u2074) r u2075； each r u2074 and r u2075 is selected regardless of (alkyl) c u2081 u208b u2086, alquenilo c u2082 u208b u2086, and alquinilo c u2082 u208b u2086 each replaced with r u1d47 between 0 and 3, and (b) - (ch u2082 cycloalkyl c u2083 u208b u2088) u2098 -Heterociclilo c u2082 u208b u2086 - (ch u2082) u2098 - c u2086 u208b u2081 u2084 - (aryl and heteroaryl u2098 ch u2082), c u2081 u208b u2089 - (ch u2082 u2098 replaced), each with between 0 and 3 r u1d9c； each r u2076 is selected regardless of alkyl c u2081 u208b u2086, (TO)Is replaced with r u1d47 between 0 and 3, and (b) - (ch u2082 cycloalkyl c u2083 u208b u2088) u2098 - heterociclilo c u2082 u208b u2086 - (ch u2082) u2098 - c u2086 u208b u2081 u2084 - (aryl and heteroaryl u2098 ch u2082), c u2081 u208b u2089 - (ch u2082) u2098 -Each replaced with between 0 and 3 r u1d48； each r u1d47 is selected regardless of Halo, - CN, and r u2077； each is selected regardless of r u1d9c (Halo), CN, and r u2077, and (b) alkyl c u2081 u208b u2086,Alquenilo c u2082 u208b u2086, and alquinilo c u20
