NG, Pui Yee,BLUM, Charles,MCPHERSON, Lauren,PERNI, Robert B.,VU, Chi B.,AHMED, Mohammed Mahmood,DISCH, Jeremy S.
申请号：
ES10830519
公开号：
ES2574927T3
申请日:
2010.10.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound represented by (a) structural formula (I): ** Formula ** a tautomer, or one of its salts, wherein: each of Z1 and Z2 is independently selected from N and CR, where: at least one of Z1 and Z2 is CR； and each R is independently selected from hydrogen, halogen, -OH, -C≡N, fluorine substituted C1-C2 alkyl, -O-C1-C2 alkyl substituted with fluorine, -S-substituted C1-C2 alkyl with fluorine, C1-C4 alkyl, -O-(C1-C4) alkyl, -S-(C1-C4) alkyl； C3-C7 cycloalkyl, -C1-C2 alkyl -N (R3) (R3), -O-CH2CH (OH) CH2OH, -O-C1-C3 alkyl -N (R3) (R3), and - N (R3) (R3)； W is selected from -O-, -NH-, -N (C1-C4 alkyl) -, -S-, -S (O) -, -S (O) 2 -and -C (R6) (R6), each R6 is independently selected from hydrogen, C1-C4 alkyl and fluorinated substituted C1-C4 alkyl, or two R6 attached to the same carbon atom are considered together to form = O, R1 is selected from an aliphatic carbocycle and a heterocycle, in where R1 is optionally substituted with one or more substituents independently selected from halogen, -C≡N, C1-C4 alkyl, = O, C3-C7 cycloalkyl, fluorine substituted C1-C2 alkyl, -O-R3, -S-R3 , - (C1-C4 alkyl) -N (R3) (R3), -N (R3) (R3), -O- (C1-C4 alkyl) -N (R3) (R3), - (C1-C4 alkyl ) -O- (C1-C4 alkyl) -N (R3) (R3), -C (O) -N (R3) (R3), and - (C1-C4 alkyl) -C (O) -N (R3 ) (R3), R2 is selected from a carbocycle and a heterocycle, wherein R2 is optionally substituted with one or more substituents independently selected from halogen, -C≡N, C1-C4 alkyl, C3-C7 cycloalkyl, C1-C2 alkyl fluorine substituted, -O-R3, -S-R3, -SO2-R3, = O, - (alq C1-C4 uyl) -N (R3) (R3), -N (R3) (R3), -O- (C1-C4 alkyl) -N (R3) (R3), - (C1-C4 alkyl) -O - (C1-C4 alkyl) -N (R3) (R3), -C (O) -N (R3) (R3), - (C1-C4 alkyl) -C (O) -N (R3) (R3) , -O-phenyl, phenyl, and a second heterocycle, and when R2 is phenyl, R2 is also optionally substituted with -O- (saturated heterocycle), 3,4-methylenedioxy, fluorine-substituted 3,4-methylenedioxy, 3, 4-ethylenedioxy, or fluorine substituted 3,4-ethylenedioxy, wherein any phe
