T _ N T ---------- ------------- Oma dacy c line Concen tra t ion (µ g /m L) T ------ -- _ (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 May 2018 (11.05.2018) WIPO I PCT omit Ill °nolo III m Oil IIII iflo oimIE (10) International Publication Number WO 2018/085216 Al (51) International Patent Classification: A61K 31/65 (2006.01) A61P 31/04 (2006.01) CO7C 237/26 (2006.01) (21) International Application Number: PCT/US2017/059165 (22) International Filing Date: 31 October 2017 (31.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/416,010 01 November 2016 (01.11.2016) US 62/422,843 16 November 2016 (16.11.2016) US 62/480,516 02 April 2017 (02.04.2017) US 62/500,611 03 May 2017 (03.05.2017) US 62/514,415 02 June 2017 (02.06.2017) US (71) Applicant: PARATEK PHARMACEUTICALS, INC. [US/US]； 75 Park Plaza, 4th Floor, Boston, MA 02116 (US). (72) Inventors: TZANIS, Evangelos L.； 3906 White Stone Road, Newtown Square, PA 19073 (US). MCGOVERN, Paul； 2176 Buttonwood Road, Berwyn, PA 19312 (US). (74) Agent: HANLEY, Elizabeth A. et al.； Mccarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM,
