Methods and compounds for conferring site-specific or local immune privilege. W O 20 18/ 217 989 Al TARGETING Say DOMAINS FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 November 2018 (29.11.2018) WIPO I PCT ~~ll~~~~~~~~ 011101VIIIVIIIVIII olo oi olo VIII 0111110/ ow (10) International Publication Number WO 2018/217989 Al (51) International Patent Classification: A61K 38/20 (2006.01) C07K 14/55 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2018/034334 (22) International Filing Date: 24 May 2018 (24.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/510,586 24 May 2017 (24.05.2017) US 62/510,816 25 May 2017 (25.05.2017) US 62/558,175 13 September 2017 (13.09.2017) US 62/595,352 06 December 2017 (06.12.2017) US (71) Applicant: PANDION THERAPEUTICS, INC. [US/US]； 700 Main Street, North, Cambridge, Massachu- setts 02139 (US). (72) Inventors: VINEY, Joanne L.； 30 Common Street, Bel- mont, Massachusetts 02478 (US). HIGGINSON-SCOTT, Nathan； 623 Tremont Street, Apt. 3, Boston, Massachusetts 02118 (US). = (74) Agent: SCOLNICK, Daniel M.； Pepper Hamilton LLP, 19th Floor, High Street Tower, 125 High Street, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise
