INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) o mum I E l° OM 101 1001101 110111110 011 (10) International Publication Number WO 2018/156609 Al WIPO I PCT (51) International Patent Classification: A61K 31/4709 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/018989 (22) International Filing Date: 21 February 2018 (21.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/461,602 21 February 2017 (21.02.2017) US 62/507,749 17 May 2017 (17.05.2017) US 62/519,819 14 June 2017 (14.06.2017) US 15/820,157 21 November 2017 (21.11.2017) US 15/820,012 21 November 2017 (21.11.2017) US 62/596,653 08 December 2017 (08.12.2017) US (71) Applicant: KURA ONCOLOGY, INC. [US/US]； 3033 Science Park Road, Suite 220, San Diego, CA 92121 (US). (72) Inventors: GUALBERTO, Antonio； 8 Larch Road, Ac- ton, MA 01720 (US). SCHOLZ, Catherine, Rose； 1 Nashua Street, Woburn, MA 01801 (US). (74) Agent: RIEGER, Dale, L. et al.； Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ
