FIG116 Ai 5-100 11 11 11 11 I L L 140 I 1 1 !I 11 1-1 N GC 1-1 00 1-1 O N C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT Iiiimmomiolollmonolomonolomiolomioluovom (10) International Publication Number WO 2018/182929 Al (51) International Patent Classification: A61L 2/20 (2006.01) (21) International Application Number: PCT/US2018/021013 (22) International Filing Date: 06 March 2018 (06.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/477,030 27 March 2017 (27.03.2017) US 62/568,850 06 October 2017 (06.10.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]； 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (72) Inventor: SHODDER, Philip, Stephen； 27 Western Ave., Apt. lc, Albany, NY 12203-1001 (US). (74) Agent: RUSSELL, Thara； Bookoff Mcandrews, PLLC, 2020 K Street, NW, Suite 400, Washington, DC 20006 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL
