INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WI P0 I P C T olimion °nolo DID Ho mil 01O 1110110111110 oimIE (10) International Publication Number WO 2018/144870 Al (51) International Patent Classification: A61K 31/275 (2006.01) CO7C 255/23 (2006.01) A61K 31/277 (2006.01) CO7C 255/31 (2006.01) A61P 35/00 (2006.01) CO7C 317/32 (2006.01) (21) International Application Number: PCT/US2018/016650 (22) International Filing Date: 02 February 2018 (02.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/454,681 03 February 2017 (03.02.2017) US 62/471,865 15 March 2017 (15.03.2017) US (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]； 1111 Franklin Street, Twelfth Floor, Oakland, CA 94607-5200 (US). (72) Inventors: NOMURA, Daniel, K.； 4532 Davenport Av- enue, Berkeley, CA 94619 (US). OLZMANN, James, A.； 2269 Mastlands Drive, Oakland, CA 94611 (US). BATE- MAN, Leslie, A.； 51 Hancock Street, #12B, Boston, MD 02114 (US). NGUYEN, Truc, B.； 660 Kinkead Way, Apt. 201, Albany, CA 94706 (US). MIYAMOTO, David, K.； 380 Green St., Cambridge, MA 02139 (US). HUFFMAN, Tucker, R.； 1821 Sapphire Way, El Dorado Hills, CA 95762 (US). ROBERTS, Allison, M.； 523 Coventry Rd, Kensington, CA 94707 (US). (74) Agent: TERRANOVA, Zachary, L. et al.； Mintz Levin Cohn Ferris Glovsky Popeo, P.C., One Financial Center, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, P
