RUF, Sven,SADOWSKI, Thorsten,WIRTH, Klaus,SCHREUDER, Herman,BUNING, Christian
申请号：
ES12701126
公开号：
ES2604556T3
申请日:
2012.01.26
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, ** Formula ** wherein A is choose from the series consisting of C (R1) and N； D is chosen from the series consisting of C (R2) and； E is chosen from the series consisting of C (R3)； L is chosen from the series consisting of C (R4) and N； where at least one and at most two of A, D or L is N； G is selected from the series consisting of R71-O-C (O) -, R72-N (R73) -C (O) - and tetrazol-5-yl； R1 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, HO-, (C1-C6) alkyl -O-, (C1-C6) alkyl-S (O) m- and NC-； R2 is selected from the series consisting of hydrogen, halogen, (C1-C7) alkyl, (C1-C6) alkyl -O-, (C1-C6) alkyl -CO-, (C1-C6) alkyl -CO-HN -, -NR12R13, Het2, cycloalkyl (C3-C7) -CsH2s- and Ar-CsH2s-, wherein s is an integer chosen from the series consisting of 0, 1, 2 and 3； R3 is R11-O-； R4 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, (C1-C6) alkyl -O-, HO-, NR12R13, Het2； R10 is selected from the series consisting of hydrogen, halogen, (C1-C6) alkyl, (C1-C6) alkyl -O-, (C1-C6) alkyl -S (O) m-, HO-, -NR12R13, Het2, phenyl-CsH2s- (O) t-, where s is a whole number chosen from the series consisting of 0, 1, 2 and 3 and where t is a whole number chosen from the series consisting of 0 and one； with the proviso that one of R1, R2, R3, R4 or R10 is a cyclic substituent； R11 is chosen from the series consisting of hydrogen and (C1-C10) alkyl； R12 and R13 are independently selected from each other in the series consisting of hydrogen and R15； R15 is (C1-C6) alkyl which is optionally substituted with one or more identical or different substituents chosen from the series consisting of halogen, HO- and (C1-C6) alkyl -O-； R30 is chosen from the series consisting of R31, cycloalkyl (C3-C7), R32-CuH2u- and Het3-CuH2u-, w
