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Compounds
专利权人:
UNIVERSITY OF HERTFORDSHIRE HIGHER EDUCATION CORPORATION
发明人:
申请号:
GB201504956
公开号:
GB201504956D0
申请日:
2015.03.24
申请国别(地区):
GB
年份:
2015
代理人:
摘要:
A compound of formula A or a pharmaceutically acceptable salt or solvate thereof: wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6 C10-aryl, and C5-C7-heteroaryl; each optionally substituted with halogen, hydroxyl, OCOR3, amino, C1-C6-alkylamino, C1-C6-dialkylamino, C1-C6­(halo)alkyl, C1-C6-(halo)-alkoxy and/or COOR3; R2 is selected from the group consisting of: C6-C10-aryl and C5-C7-heteroaryl; each optionally substituted with halogen, hydroxyl, OCOR3 , amino, C1-C6 alkylamino, C1-C6-dialkylamino, C1-C6-(halo)alkyl C1-C6-(halo)alkoxy and/or COOR3; R3 is independently at each occurrence selected from the group consisting of: hydrogen and C1-C2-alkyl; n is an integer from 1 to 10 inclusive. Preferably, R1 is phenyl or methyl; R2 is phenyl, 2-pyridyl or 3-pyridyl; R3 is H; n is 1 or 2. These compounds find use as neuroprotective agents, in treatment of neurological and neuropsychiatric disorders and in the treatment of diseases associated with, accompanied by or caused by mitochondrial stress.
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