COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES AGONISTES SELECTIFS DU RECEPTEUR DE LA MELANOCORTINE 1, ET METHODES THERAPEUTIQUES D'UTILISATION DE CES COMPOSITIONS
ABDEL-MALEK, ZALFA A.,KOIKOV, LEONID,KNITTEL, JAMES J.
申请号：
CA2892144
公开号：
CA2892144A1
申请日:
2013.11.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1-X2-CO-X3-X4-X5-(Trp) n -NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are pharmaceutical compositions including Formula I peptide agonists of MC1R and methods of treating skin diseases and disorders that include administering to an individual in need thereof a therapeutic amount of a Formula I peptide. The peptides, pharmaceutical compositions, and methods described herein are useful in the treatment of diseases and disorders that benefit from agonism of MCIR, including melanoma, basal cell carcinoma, squamous cell carcinoma, porphyria, polymorphous light eruption, vitiligo, and solar urticaria.
