WIMMER, ECKARD;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;MUELLER; STEFFEN;MUELLER, STEFFEN
发明人:
MUELLER, STEFFEN,WIMMER, ECKARD,COLLINS, PETER L.,LE NOUEN, CYRIL,BROCK, LINDA G.,BUCHHOLZ, URSULA J.,DINAPOLI, JOSHUA MARC
申请号：
CA2900713
公开号：
CA2900713A1
申请日:
2014.02.07
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
