The United States of America, as represented by The Secretary, Department of Health and Human Services;Steffen Mueller;Eckard Wimmer
发明人:
Mueller, Steffen,Wimmer, Eckard,Collins, Peter L.,Le Nouen, Cyril,Brock, Linda G.,Buchholz, Ursula J.,Dinapoli, Joshua Marc
申请号：
AU2014214763
公开号：
AU2014214763A1
申请日:
2014.02.07
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
