Steffen MUELLER;THE UNITED OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;Eckard WIMMER
发明人:
Peter L. Collins,Cyril Le Nouën,Linda G. Brock,Ursula J. Buchholz,Joshua Marc DiNapoli,Steffen Mueller,Eckard Wimmer
申请号：
US14766620
公开号：
US20150368622A1
申请日:
2014.02.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
