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ATTENUATION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS BY GENOME SCALE CODON-PAIR DEOPTIMIZATION
专利权人:
Steffen MUELLER;THE UNITED OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;Eckard WIMMER
发明人:
Peter L. Collins,Cyril Le Nouën,Linda G. Brock,Ursula J. Buchholz,Joshua Marc DiNapoli,Steffen Mueller,Eckard Wimmer
申请号:
US14766620
公开号:
US20150368622A1
申请日:
2014.02.07
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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