The USA, as represented by the Secretary, Dept. of Health and Human Services;The Research Foundation for the State University of New York
发明人:
Peter L. Collins,Cyril Le Nouën,Linda G. Brock,Ursula J. Buchholz,Joshua Marc DiNapoli,Steffen Mueller,Eckard Wimmer
申请号：
US15924012
公开号：
US20180208906A1
申请日:
2018.03.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
