The United of America, as represented by the Secretary, Department of Health and Human Services;The Research Foundation for the State University of New York
发明人:
MUELLER, Steffen,WIMMER, Eckard,COLLINS, Peter L.,LE NOUEN, Cyril,BROCK, Linda G.,BUCHHOLZ, Ursula J.,DINAPOLI, Joshua Marc
申请号：
AU2020203460
公开号：
AU2020203460A1
申请日:
2020.05.26
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020203460A120200618.pdf#####ABSTRACT Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
