Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia.Specifically provided is a macrocyclic polypeptide represented by formula (I)[wherein A is selected from the linking groups A1 to A6； Xaa1 is a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent； Xaa2 is a residue of an aromatic amino acid or a neutral amino acid； Xaa3 is a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid； Xaa4 is Ser, Thr, Ala, or mS； Xaa5 is Gly or Ser； Xaa6 is a residue of a basic amino acid or a neutral amino acid； Xaa7 is a residue of a neutral amino acid or an acidic amino acid； Xaa8 is a residue of an aromatic amino acid； Xaa9 is a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid； Xaa10 is a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid； Xaa11 is a residue of an aromatic amino acid； and Xaa12 is a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof.
