YAMAGUCHI, Takahiro,MORI, Yutaka,SAITO, Hironao,KUBOTA, Hideki,FURUKAWA, Akihiro,OTSUKA, Eri,ISHIGAI, Yutaka,IJIRI, Hiroshi,REID, Patrick
申请号：
EP17850903
公开号：
EP3514167A4
申请日:
2017.09.13
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia.Specifically provided is a macrocyclic polypeptide represented by formula (I)[wherein A is selected from the linking groups Ato A； Xis a residue of an aliphatic amino acid, an aromatic amino acid, a basic amino acid, a neutral amino acid, or an acidic amino acid, or is absent； Xis a residue of an aromatic amino acid or a neutral amino acid； Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid； Xaa4 is Ser, Thr, Ala, orS； Xis Gly or Ser； Xis a residue of a basic amino acid or a neutral amino acid； Xis a residue of a neutral amino acid or an acidic amino acid； Xis a residue of an aromatic amino acid； Xis a residue of an aliphatic amino acid, a neutral amino acid, or an aromatic amino acid； Xis a residue of a basic amino acid, an aliphatic amino acid, an aromatic amino acid, or a neutral amino acid； Xis a residue of an aromatic amino acid； and Xis a residue of an aliphatic amino acid, an aromatic amino acid, or a basic amino acid], or a pharmacologically acceptable salt thereof.
