PROBLEM TO BE SOLVED: To provide an angiogenesis promoter, a method for promoting angiogenesis, an angiogenesis inhibitor, a method for inhibiting angiogenesis, and a method for screening an angiogenesis regulation composition in each of which novel genes involved in the mechanism of regulating angiogenesis are utilized.SOLUTION: The angiogenesis promoter comprises as an active ingredient a polynucleotide containing the base sequence shown in sequence No.1 (NCBI Accession No. AB044755) or a like polynucleotide, a polypeptide containing the amino acid sequence shown in sequence No.2 (NCBI Accession No. BAA96781) or a like polypeptide, an inhibitor of a polynucleotide containing the base sequence shown in sequence No.3 (NCBI Accession No. AB077880) or a like inhibitor, or an inhibitor of a polypeptide containing the amino acid sequence shown in sequence No.4 (NCBI Accession No. BAB83896) or a like inhibitor. The angiogenesis inhibitor comprises as an active ingredient an inhibitor of a polynucleotide containing the amino acid sequence shown in sequence No.1 (NCBI Accession No. AB044755) or a like inhibitor, an inhibitor of a polypeptide containing the amino acid sequence shown in sequence No.2 (NCBI Accession No. BAA96781) or a like inhibitor, a polynucleotide containing the base sequence shown in sequence No.3 (NCBI Accession No. AB077880) or a like polynucleotide, or a polypeptide containing the amino acid sequence shown in sequence No.4 (NCBI Accession No. BAB83896) or a like polypeptide.【課題】血管新生の制御機構に関わる新規遺伝子を利用する、血管新生促進剤、血管新生の促進方法、血管新生抑制剤、血管新生の抑制方法、および、血管新生制御組成物のスクリーニング方法を提供する。【解決手段】血管新生促進剤は、配列番号１に記載の塩基配列を含有するポリヌクレオチド等、配列番号２に記載のアミノ酸配列を含有するポリペプチド等、配列番号３に記載の塩基配列を含有するポリヌクレオチドの阻害物質等または配列番号４に記載のアミノ酸配列を含有するポリペプチドの阻害物質等を有効成分として含む。血管新生抑制剤は、配列番号１に記載の塩基配列を含有するポリヌクレオチドの阻害物質等、配列番号２に記載のアミノ酸配列を含有するポリペプチドの阻害物質等、配列番号３に記載の塩基配列を含有するポリヌクレオチド等または配列番号４に記載のアミノ酸配列を含有するポリペプチド等を有効成分として含む。【選択図】図２
