Provided is a compound which can promote angiogenesis by inhibiting the function of TSP1, and is useful in the treatment or prevention of diseases such as critical limb ischemia. Specifically provided is a macrocyclic polypeptide represented by formula (1) [in the formula: A is selected from among linking groups A1 to A6； Xaa1 is an aliphatic amino acid, aromatic amino acid, basic amino acid, neutral amino acid, or acidic amino acid residue, or is not present； Xaa2 is an aromatic amino acid or neutral amino acid residue； Xaa3 is an aliphatic amino acid, aromatic amino acid, or basic amino acid residue； Xaa4 is Ser, Thr, Ala, or mS； Xaa5 is Gly or Ser； Xaa6 is a basic amino acid or neutral amino acid residue； Xaa7 is a neutral amino acid or acidic amino acid residue； Xaa8 is an aromatic amino acid residue； Xaa9 is an aliphatic amino acid, neutral amino acid, or aromatic amino acid residue； Xaa10 is a basic amino acid, aliphatic amino acid, aromatic amino acid, or neutral amino acid residue； Xaa11 is an aromatic amino acid residue； and Xaa12 is an aliphatic amino acid, aromatic amino acid, or basic amino acid residue], or a pharmacologically acceptable salt thereof.本發明之課題係提供一種化合物，其可藉由抑制TSP1的功能而促進血管生成，且有用於嚴重下肢缺血等之疾病之治療或預防。解決手段為一種式(I)所表示的大環狀多肽或其藥理學上可容許的鹽等，[式中，A係選自連結基A1~A6，Xaa1係脂肪族胺基酸、芳香族胺基酸、鹼性胺基酸、中性胺基酸、或酸性胺基酸之殘基，或不存在；Xaa2係芳香族胺基酸或中性胺基酸之殘基；Xaa3係脂肪族胺基酸、芳香族胺基酸、或鹼性胺基酸之殘基；Xaa4係Ser、Thr、Ala、或mS；Xaa5係Gly或Ser；Xaa6係鹼性胺基酸或中性胺基酸之殘基；Xaa7係中性胺基酸或酸性胺基酸之殘基；Xaa8係芳香族胺基酸殘基；Xaa9係脂肪族胺基酸、中性胺基酸、或芳香族胺基酸之殘基；Xaa10係鹼性胺基酸、脂肪族胺基酸、芳香族胺基酸、或中性胺基酸之殘基；Xaa11係芳香族胺基酸殘基；Xaa12係脂肪族胺基酸、芳香族胺基酸、或鹼性胺基酸之殘基]。
