您的位置: 首页 > 农业专利 > 详情页

Exendin-4 functionalised derivatives
专利权人:
SANOFI
发明人:
申请号:
ARP130104911
公开号:
AR094178A1
申请日:
2013.12.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Claim 1: Peptide compound having the formula (1): R¹-Z-R² (1) wherein Z is a peptide residue having the formula (2): Tyr-Aib-X³-GIy-Thr-Ser-Asp- Leu-Ser-X¹²-Gln-X¹⁴-X¹⁵-X¹⁶-X¹⁷-X¹⁸-X¹⁹-X²⁰-X²¹-Phe-Ile-GIu-Trp-Leu-Lys-X²⁸-X²⁹-Gly-Pro-Ser-Ser-Gly- Ala-Pro-Pro-Pro-Ser-X⁴⁰ (2);X3 represents other amino acids selected between Gln, Glu and HS; X12 represents other amino acids selected between ile and Lys; x1-83088 represents the rest of amino acids, which has a side chain composed of - nh-8322 group;a. The transverse chain group - nh-83222 was combined with - C (o) - r83099;en donde R puede ser un resto que comprende hasta 50 o hasta 100 tomos de carbono y opcionalmente hetero tomos seleccionados entre hal geno NOS y 2Fo PX representa un resto de amino cido seleccionado entre Asp y Glu X representa un resto de amino cido seleccionado entre Ser The results showed that x2 O1 represented the residual amino acids selected from ASP, Glu and Leu; x2 83212 represented the residual amino acids selected from ASN and ALA; x2 o8313 represented the residual amino acids selected from Gly, thr and D-Ala; X 8308040 was not present or represented Lys; R1 represented nh832222; and the remaining amino acids selected from Gly, thr and D-Ala were represented;R2 represents c-final group, selected from Oh to nh832222;Or salt or water Claim 27: the compound used in claim 26, which is present in the pharmaceutical ingredient as an active agent and has at least one acceptable pharmaceutical vehicle. Claim 31: compounds from any of the 26 to 30 claims for the treatment or prevention of hyperglycemia, type 2 diabetes and obesity.Reivindicación 1: Compuesto peptídico que tiene la fórmula (1): R¹-Z-R² (1) en donde Z es un resto peptídico que tiene la fórmula (2): Tyr-Aib-X³-GIy-Thr-Ser-Asp-Leu-Ser-X¹²-Gln-X¹⁴-X¹⁵-X¹⁶-X¹⁷-X¹⁸-X¹⁹-X²⁰-X²¹-Phe-Ile-GIu-Trp-Leu-Lys-X²⁸-X²⁹-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X⁴⁰ (2); X³ representa un resto de aminoácido seleccionado entre Gln, Glu y His; X¹² represent
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充