N-(PHENYLSULFONYL) BENZAMIDES ET COMPOSES APPARENTES EN TANT QU'INHIBITEURS DE BCL-2

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,CHEN, JIANYONG

申请号：

CA3031419

公开号：

CA3031419A1

申请日:

2017.08.04

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1 , X2, X3 R1a, R1b E, and = are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bc1-2 protein inhibition such as cancer.

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