PIPERIDINES EN TANT QU'INHIBITEURS COVALENTS DE LA MENINE

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,AGUILAR, ANGELO,XU, SHILIN,HUANG, LIYUE,STUCKEY, JEANNE,TIANFENG, XU

申请号：

CA3058448

公开号：

CA3058448A1

申请日:

2018.03.30

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R1a, R1b, R1c, R1d, R2, R3, R8a, R8b, R10, X, Z2, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.

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