PIPÉRIDINES EN TANT QU'INHIBITEURS COVALENTS DE LA MÉNINE

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专利权人:

The Regents of The University of Michigan

发明人:

WANG, Shaomeng,AGUILAR, Angelo,XU, Shilin,HUANG, Liyue,STUCKEY, Jeanne,TIANFENG, Xu

申请号：

EP18776755

公开号：

EP3600313A4

申请日:

2018.03.30

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R1a, R1b, R1c, R1d, R2, R3, R8a, R8b, R10, X, Z2, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.

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http://www.ckcest.cn/home/