COMPOSES PIPERIDINE EN TANT QU'INHIBITEURS COVALENTS DE LA MENINE

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

WANG, SHAOMENG,XU, SHILIN,AGUILAR, ANGELO,HUANG, LIYUE,STUCKEY, JEANNE,ZHANG, MENG

申请号：

CA3093454

公开号：

CA3093454A1

申请日:

2019.03.29

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R1c, R1d, R1e, R2, R3, R8a, R8b, L, X, Z1, and Z2 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to menin inhibition such as cancer.

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