PIPERIDINES AS COVALENT MENIN INHIBITORS

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专利权人:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人:

Shaomeng Wang,Angelo Aguilar,Shilin Xu,Liyue Huang,Jeanne Stuckey,Tianfeng Xu

申请号：

US16497856

公开号：

US20200022953A1

申请日:

2018.03.30

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present disclosure provides compounds represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, R1a, R1b, R1c, R1d, R2, R3, R8a, R8b, R10, X, Z2, m, and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to menin inhibition such as cancer.

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