SAHMYOOK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;삼육대학교산학협력단
发明人:
PARK, Myoung Hwan,박명환
申请号：
KRKR2019/012217
公开号：
WO2020/060275A1
申请日:
2019.09.20
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to an ultrasound-induced drug delivery system using a drug carrier in which a plurality of nanobubbles and a high concentration of a drug are contained in a single microcapsule and, more particularly, relates to a method for preparing a drug carrier, in which a high concentration of a drug and a plurality of nanobubbles are capsulated together, by generating nanobubbles in oil having the drug dissolved therein by using a nanobubble generation apparatus, and then microcapsulating the resulting oil, and an ultrasound-induced drug delivery system using same. A drug carrier using nanobubbles according to the present invention is prepared as a drug carrier in which a drug and nanobubbles are capsulated together using a nanobubble solution, and thus, in particular, when ultrasound is applied, nanobubbles collapse or agglomerate, resulting in the effect of maximizing drug delivery efficiency. In addition, the drug carrier according to the present invention contains a plurality of nanobubbles inside a microcapsule, and thus not only can be used as a drug carrier, but can also be used as a contrast agent, and a drug carrier prepared according to the method for preparing a drug carrier in which a drug and nanobubbles are capsulated together can simultaneously perform in-vivo diagnosis and treatment.La présente invention concerne un système d'administration de médicament induit par ultrasons utilisant un vecteur de médicament dans lequel une pluralité de nanobulles et une concentration élevée d'un médicament sont contenus dans une microcapsule unique et concerne plus particulièrement, un procédé de préparation d'un vecteur de médicament, dans lequel une concentration élevée d'un médicament et une pluralité de nanobulles sont encapsulées ensemble, par la génération de nanobulles dans de l'huile dans laquelle le médicament est dissous à l'aide d'un appareil de génération de nanobulles, suivie par le microcapsulage de l'huile résultante, et un systèm
