The present invention provides a vesicle for delivering a drug to the brain a conjugate a composition containing same and a method for administering same. A composition for administration to a subject according to a dosing regimen the composition containing a carrier for drug delivery wherein the dosing regimen includes the administration of the composition to a subject who has been made to fast or in whom hypoglycemia has been induced and the induction of a rise in blood sugar levels in the subject and the outer surface of the carrier in the composition is modified by a GLUT1 ligand.