The present invention provides a synchronic monitor system for drug delivery induced by ultrasound. A first ultrasound is applied in the drug delivery, and the first ultrasound apparatus emits a first ultrasound to a vessel of a target zone to let a drug pass through the vessel into the lesion zone. The abovementioned system comprises a second ultrasound apparatus and software. The second ultrasound apparatus has a transducer, and the transducer is used to emit a second ultrasound to the vessel to determine several information of the blood flow. The software is installed in the second ultrasound apparatus to collect all the information of the blood flow, and calculate an extravasation of the drug in the lesion zone via an equation according to the information of the blood flow. The present invention discloses a method using the same.本發明提供一種以超音波影像監控超音波目標藥物傳輸系統。可即時監測超音波所引發藥物在目標區域的滲透濃度,係利用第一超音波裝置發射第一超音波信號於目標區域之血管,使藥物通過血管進入病灶區域。並包含一第二超音波裝置與一程式。第二超音波裝置包含有一探頭,探頭發射第二超音波信號於血管以量測其內之複數個血流資訊。程式被載入於第二超音波裝置,該程式收集該些血流資訊並將該些血流資訊帶入第一計算式計算出藥物於病灶區域之滲透量。同時,本發明亦提供同步監控超音波導引藥物傳輸機制的方法。