The present invention provides a synchronic monitor system using real-time ultrasound image to monitor the permeable concentration of the targeted tissue for drug delivery induced by ultrasound. The drug delivery is performed by using a first ultrasound apparatus to emit a first ultrasound to a blood vessel of the targeted tissue to allow a drug passing through the blood vessel into a lesion zone. The synchronic monitor system comprises a second ultrasound apparatus and software. The second ultrasound apparatus has a transducer, and the transducer is used to emit a second ultrasound to the blood vessel to determine several information of the blood flow. The software is installed in the second ultrasound apparatus to collect the information of the blood flow, and calculate an extravasation of the drug in the lesion zone according to the information of the blood flow via a first equation. The present invention discloses a method using the same.
