Lynn Macdonald,Andrew J. Murphy,John McWhirter,Naxin Tu,Vera Voronina,Cagan Gurer,Karolina Meagher,Sean Stevens
申请号:
US14799355
公开号:
US20160021856A1
申请日:
2015.07.14
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of making the same. Various methods of using the genetically modified non-human animal are also provided.