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Substituted oxazolidinones and their use
专利权人:
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
ALLERHEILIGEN, SWEN,BAUSER, MARCUS,SCHIROK, HARTMUT,HAERTER, MICHAEL,SIEGEL, STEPHAN,RESTER, ULRICH,GERDES, CHRISTOPH,HEITMEIER, STEFAN,VON DEGENFELD, GEORGES,BUCHMUELLER, ANJA,DITTRICH-WENGENROTH, EL
申请号:
ES08773422
公开号:
ES2377422T3
申请日:
2008.06.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compound of formula in which R 1 represents a group of formula in which it is the point of attachment to the phenyl ring, R 5 represents hydrogen or C 1 -C 3 alkyl, the alkyl may be substituted with a hydroxy substituent, R 6 represents hydrogen, trifluoromethyl, trifluoromethoxy, difluroromethoxy, C1-C3 alkyl or C1-C4 alkoxy, wherein alkoxy may be substituted with a substituent, the substituent being selected from the group consisting of halogen, hydroxy, trifluoromethyl, aminocarbonyl, C1-C3 alkoxy, C1-C3 alkylcarbonyl , C1C4-aminocarbonyl and morpholinocarbonyl, R7 represents hydrogen, C1-C3 alkyl or C1-C4 alkoxy, wherein C2-C3 alkyl and C2-C4 alkoxy can be substituted with a hydroxy substituent, R8 represents hydrogen or C1-C3 alkyl, 20 wherein C2-C3 alkyl may be substituted with a hydroxy substituent, R9 represents hydrogen or C1-C3 alkyl, wherein C2-C3 alkyl may be substituted with a hydroxy substituent, R2 represents chlorine, trifluoromethyl, trifiuoromethoxy, difluoromethoxy, methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, methoxymethyl, ethoxymethyl or cyclopropyl, R3 represents hydrogen, C1-C3 alkoxy or C1-C3-amino alkyl, R4 represents hydrogen or methyl, or one of its salts, its solvates or the solvates of its salts.Compuesto de fórmula en la que R1 representa un grupo de fórmula en las que es el punto de unión al anillo de fenilo, R5 representa hidrógeno o alquilo C1-C3, pudiendo estar el alquilo sustituido con un sustituyente hidroxi, R6 representa hidrógeno, trifluorometilo, trifluorometoxi, diflurorometoxi, alquilo C1-C3 o alcoxi C1-C4, en donde alcoxi puede estar sustituido con un sustituyente, seleccionándose el sustituyente del grupo constituido por halógeno, hidroxi, trifluorometilo, aminocarbonilo, alcoxi C1-C3, alquil C1-C3-carbonilo, alquil C1C4-aminocarbonilo y morfolinocarbonilo, R7 representa hidrógeno, alquilo C1-C3 o alcoxi C1-C4, en donde alquilo C2-C3 y alcoxi C2-C4 pueden estar sustituidos con un sustituyente hidroxi, R8 represen
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