Skolnick, Phil,Basile, Anthony,Chen, Zhengming,Epstein, Joseph W.
申请号：
ES13189441
公开号：
ES2691050T3
申请日:
2006.07.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula II: * * * * formula or a pharmaceutically acceptable Salt thereof, in which R1 and R2 are independently selected from Hydrogen, alkyl C1 - 10Alquenilo C3 and C3 - 10 - 10 alquinilo unsubstituted alkyl -, and 10 alquenilo C1, C3 and C3 - 10 - 10 alquinilo replaced, in which the Substituent is one or more from hydroxyl, cyano, halogen10 6 - alkoxy C1, C1 6 - alkoxy substituted with aryl, ariloxi, ariloxi substituted with one or more alkyl Halogen C1, C1 - 6 - 6, alkyl substituted with one or more regardless of cyano and HalogenC1-4 alkoxy and haloalcoxi c1-4 R3 is selected from Hydrogen, alkyl alcoxicarbonilo C1 C1 - 6, - 6, - 6 alcanoílo C2, C3, C4 cicloalcanoílo cycloalkyl - 8 - 9, aryl, heteroaryl,Saturated Heterocyclic Compound, alquenilo C2 - 10 - 10, alquinilo C2, C1 and C2 alquenilo alkyl - 6, - 10 and - 10 alquinilo C2 replaced, in which the Substituent is one or more between Ciano, halogenHydroxyl alkoxy C1 - 6 - 6 alcoxicarbonilo C1, C2, C1 alcanoílo alquiloxicarboniloxi - 6, - 6, - 6 alcanoiloxi C1, C3 C3 cicloalquiloxi cycloalkyl - 8 - 8 - 9, cicloalcanoílo C4, aryl, ariloxi,Saturated Heterocyclic and heteroaryl compound R4 and R5 are independently Hydrogen or 1 - 4 substituents selected regardless of halogen, alkyl alquenilo C1 - C2 - 4 3Alquinilo c2-4, Halo c1-3 alkyl, cyano, cycloalkyl Hydroxy, alkoxy C1 - C3 - 5, 3 (c1-3) - alkoxy alkyl c1-3, carboxy c1-3 alkyl, Halo 3 alcanoílo C1, C1 - 3 - alkoxy, Nitro, amino,Alkyl (c1-3) and dialkyl amino - (3 - amino - C1) and under the condition that this Compound is not 3 - methyl - 1 - (2 - naftalen - il) - 3 - aza Bicyclo [3.1.0] hexane.Un compuesto de la fórmula II siguiente:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: R1 y R2 se seleccionan independientemente de entre hidrógeno, alquilo C1-10, alquenilo C3-10 y alquinilo C3-10 no sustituidos, y alquilo C1-10, alquenilo C3-10 y alquinilo C3-10 sustituidos, en los que el sustituyente es uno o más de entre hi
