KADEREIT, DIETER,SCHAEFER, MATTHIAS,HACHTEL, STEPHANIE,DIETRICH, AXEL,HUEBSCHLE, THOMAS,GILLE, ANDREAS,HISS, KATRIN
申请号：
ES11700403
公开号：
ES2448645T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of the formula I, in any of its stereoisomeric forms, or a mixture of stereoisomeric forms in any proportion, or one of its physiologically acceptable salts, or a solvatophysiologically acceptable of any of them, ** Formula ** in which A is chosen between NH, O and S； R1 is selected from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl-CtH2t- and Het-CtH2t-, where t is selected between 0, 1, 2 and 3； R2 is chosen from phenyl and a residue of an aromatic monocyclic heterocycle, from 5 members to 6 members comprising 1, 2 or 3 identical ring heteroatoms chosen from N, O and S, where one of the ring nitrogen atoms can carrying a hydrogen atom or an R21 substituent, and wherein the phenyl and the residue of the aromatic heterocycle are optionally substituted on one or more identical or different R22 ring carbon atoms； R3 is chosen from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl-Hu2- and Het-CvH2v-, where u and v are chosen between 1 and 2, or R3 is a residue of a saturated or unsaturated monocyclic or bicyclic ring, from 3 members to 10 members, comprising 0, 1, 2, 3 or 4 heteroatoms in the identical or different ring, chosen from N, O and S, where one or two of the ring's nitrogen atoms can carry a hydrogen atom or a (C1-C4) alkyl substituent and one or two of the ring's sulfur atoms can carry one or two oxo groups, and where the ring residue is optionally substituted on one or more identical or different R31 ring carbon constituents, provided that R3 cannot be (C1-C6) alkyl if A is S； R21 is chosen from (C1-C4) alkyl, cycloalkyl (C3-C7) -CwH2w- and oxy, where w is chosen from 0, 1 and 2； R22 is selected from halogen, hydroxy, (C1-C4) alkyl -, (C1-C4) alkyloxy, (C1-C4) alkyl -S (O) m-, amino, nitro, cyano, hydroxycarbonyl, (C1-C4 alkyloxy) ) -carbonyl, aminocarbonyl, aminosulfonyl, R23 and R23-O-； R23 is a residue of a saturated monocyclic or bicyclic ring of 3 members to 7 members, comprising 0, 1, 2,3 or 4 identica
