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Carboxylic acid derivatives with an oxazolo [4,5-d] pyrimidine ring
专利权人:
SANOFI
发明人:
KADEREIT, DIETER,SCHÄFER, MATTHIAS,HACHTEL, STEPHANIE,HUEBSCHLE, THOMAS,HISS, KATRIN,HAAG-DIERGARTEN, SILKE
申请号:
ES12735503
公开号:
ES2547110T3
申请日:
2012.07.06
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of the formula I in one of its arbitrary stereoisomeric forms or a mixture of stereoisomeric forms in an arbitrary ratio or a physiologically acceptable salt thereof or a physiologically acceptable solvate of such a compound or of such a salt ** Formula ** where A is chosen from NH, O and S; X is cycloalkane (C3-C7) -diyl, which is optionally substituted with one or more identical or different substituents chosen from (C1-C4) alkyl, fluorine and hydroxy; R1 is chosen from hydrogen, (C1-C4) alkyl and cycloalkyl (C3-C7) -CzH2z-, wherein z is chosen from 0, 1 and 2; R2a, R2b and R2c are chosen, independently of one another, from hydrogen, halogen, hydroxy, (C1-C4) alkyl -, cycloalkyl (C3-C5) -CzH2z-, alkyloxy (C1-C4), alkyl (C1-C4) ) -S (O) m-, amino, nitro, cyano, hydroxycarbonyl, (C1-C4) alkyloxycarbonyl, aminocarbonyl and aminosulfonyl, wherein z is selected from 0, 1 and 2; R3 is chosen from alkyl (C1-C6), alkenyl (C2-C6), alkynyl (C2-C6), cycloalkyl (C3-C7) -CuH2u- and Het-CvH2v-, where u and v are chosen from 1 and 2, or R3 represents a radical of a monocyclic or bicyclic ring, saturated or unsaturated, from 3 members to 10 members, containing 0, 1, 2, 3 or 4 heteroatoms of the same or different ring that are chosen from N, O and S, wherein one or two of the ring's nitrogen atoms can carry a hydrogen atom or a (C1-C4) alkyl substituent, and one or two of the ring's sulfur atoms can carry one or two oxo groups, and where the radical of a ring is optionally substituted at one or several carbon atoms of the ring by the same or different R31 substituents; R31 is selected from halogen, (C1-C4) alkyl, (C3-C7) cycloalkyl, hydroxy, (C1-C4) alkyloxy, oxo, (C1-C4) alkyl -S (O) m-, amino, (C1-alkyl) -C4) -amino, di (((C1-C4) alkyl) - amino, (C1-C4) alkylcarbonylamino, (C1-C4) alkyl-sulfonylamino, nitro, cyano, (C1-C4) alkylcarbonyl, aminosulfonyl, (C1-C4) alkyl-amino-sulfonyl and di ((C1-C4) alkyl) -aminosulfonyl; Het represents a radical of a saturated monocyclic
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